Author: Hermesh, Tamar; Moltedo, Bruno; López, Carolina B.; Moran, Thomas M.
Title: Buying Time—The Immune System Determinants of the Incubation Period to Respiratory Viruses Document date: 2010_11_18
ID: 0yqv2osb_22
Snippet: The transcriptional regulation of type I IFNs has been comprehensively reviewed [51] . In short, IFN-β is the first type I IFN to be induced following viral recognition. Transcription of IFN-β mRNA requires binding of three groups of transcription factors to the regulatory domain of the IFN promoter; NFκB, activating transcription factor 2 (ATF2)/c-Jun and interferon regulatory factors 3 and 7 (IRF-3 and IRF-7). The activation of all these fac.....
Document: The transcriptional regulation of type I IFNs has been comprehensively reviewed [51] . In short, IFN-β is the first type I IFN to be induced following viral recognition. Transcription of IFN-β mRNA requires binding of three groups of transcription factors to the regulatory domain of the IFN promoter; NFκB, activating transcription factor 2 (ATF2)/c-Jun and interferon regulatory factors 3 and 7 (IRF-3 and IRF-7). The activation of all these factors in response to virus infection is induced by triggering either the RLR or TLR systems ( Figure 1 ).
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