Author: Bohmwald, Karen; Gálvez, Nicolás M. S.; Ríos, Mariana; Kalergis, Alexis M.
Title: Neurologic Alterations Due to Respiratory Virus Infections Document date: 2018_10_26
ID: 0rlotyz3_54
Snippet: Remarkably, no studies have been performed describing the ability of hMPV to cause CNS damage in mice. However, it has been described that hMPV can persist in the lung of mice after acute infection (Alvarez et al., 2004; Liu et al., 2009 ). This characteristic could be aiding the virus to eventually reach the CNS, as the latency state is achieved through the infection of neuronal processes that innervate the lungs, as the genetic material of the .....
Document: Remarkably, no studies have been performed describing the ability of hMPV to cause CNS damage in mice. However, it has been described that hMPV can persist in the lung of mice after acute infection (Alvarez et al., 2004; Liu et al., 2009 ). This characteristic could be aiding the virus to eventually reach the CNS, as the latency state is achieved through the infection of neuronal processes that innervate the lungs, as the genetic material of the virus can be detected in them (Liu et al., 2009 ). Moreover, as described by the authors, latent virus can be reactivated upon treatment with immunosuppressive drugs such as steroids.
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