Author: Hsu, Shih-Hsien; Yeh, Ming-Lun; Wang, Shen-Nien
Title: New Insights in Recurrent HCV Infection after Liver Transplantation Document date: 2013_4_23
ID: 0hbeso65_45
Snippet: In addition to cell surface expressed host factors, HCV internalization and fusion are complex processes that also offer several targets for antivirals. A recent study demonstrated that long phosphorothioate oligonucleotides (PS-ON) inhibited HCV internalization without affecting viral binding and replication [117] . The human liver-chimeric Alb-uPA/SCID mouse model also showed that PS-ON block de novo HCV infection. These data shed light on the .....
Document: In addition to cell surface expressed host factors, HCV internalization and fusion are complex processes that also offer several targets for antivirals. A recent study demonstrated that long phosphorothioate oligonucleotides (PS-ON) inhibited HCV internalization without affecting viral binding and replication [117] . The human liver-chimeric Alb-uPA/SCID mouse model also showed that PS-ON block de novo HCV infection. These data shed light on the promise of PS-ON as future clinical solution.
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