Neurologic Alterations Due to Respiratory Virus Infections

Bohmwald, Karen; Gálvez, Nicolás M. S.; Ríos, Mariana; Kalergis, Alexis M.

Moreover, viral RNA was detected in CSF from adult mice, but this does not discard the possibility that in neonates, this also occurs and that IAV furthermore invades the CNS by crossing the blood-CSF barrier (Yu et al., 2014) . According to these findings, specifically the detection of the viral RNA in the hippocampus, Hosseini et al. (2018) recently evaluated three different mouse-adapted IAVs: two non-neurotropic virus H1N1 (PR8) and H3N2 (maHK68); one neurotropic virus H7N7 (rSC35M). As they expected, no viral particles were found in the brain of H1N1-infected mice, although a few amounts of viral particles were found in H3N2-infected mice and viral detection was evident in several brain zones in H7N7-infected mice (Hosseini et al., 2018) . Therefore, no signs of pathological changes were detected in the brain of H1N1-and H3N2-infected mice, but in the H7N7-infected mice, there was a moderate immune cell infiltration and zones with gliosis (Hosseini et al., 2018) .