Selected article for: "clinical study and cohort study"
Author: Hsu, Shih-Hsien; Yeh, Ming-Lun; Wang, Shen-Nien
Title: New Insights in Recurrent HCV Infection after Liver Transplantation
  • Document date: 2013_4_23
    • ID: 0hbeso65_14
    Snippet: Recently, genetic variation in the region of the IL28B gene on chromosome 19, coding for IFN-3, has been demonstrated to be strongly associated with SVR in patients with genotype 1 chronic HCV infection who are treated with pEG-IFN plus RBV in the nontransplant setting [23, 24] . IL28B polymorphism has also been associated with spontaneous HCV clearance [25] . One cohort study, Clinical and Developmental Immunology 3 which included 189 consecutiv.....
    Document: Recently, genetic variation in the region of the IL28B gene on chromosome 19, coding for IFN-3, has been demonstrated to be strongly associated with SVR in patients with genotype 1 chronic HCV infection who are treated with pEG-IFN plus RBV in the nontransplant setting [23, 24] . IL28B polymorphism has also been associated with spontaneous HCV clearance [25] . One cohort study, Clinical and Developmental Immunology 3 which included 189 consecutive HCV patients undergoing LT, aimed to determine the prevalence and impact on clinical outcomes of donor and recipient IL28B genotypes among liver transplant recipients [26] . The authors suggested that recipient IL28B TT genotype is associated with more severe histological recurrence of HCV after LT and CC donor grafts might be preferentially allocated to recipients with HCV infection.

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