Author: Ojosnegros, Samuel; Beerenwinkel, Niko
Title: Models of RNA virus evolution and their roles in vaccine design Document date: 2010_11_3
ID: 0q928h3b_6
Snippet: The mutation rate of RNA viruses is about a million times larger than the human mutation rate [6] . Thus, RNA viruses display a huge genetic diversity and this feature is critical for survival of the virus [7, 8] . Virus populations are exposed to fluctuating environments when migrating through different organs and tissues of the host organism and when exposed to immune responses mounted by the host. Transmission to a new host is typically associ.....
Document: The mutation rate of RNA viruses is about a million times larger than the human mutation rate [6] . Thus, RNA viruses display a huge genetic diversity and this feature is critical for survival of the virus [7, 8] . Virus populations are exposed to fluctuating environments when migrating through different organs and tissues of the host organism and when exposed to immune responses mounted by the host. Transmission to a new host is typically associated with both traversing various tissues and facing new immune responses, and therefore it represents a major bottleneck for the virus population. The genetic diversity of RNA viruses makes it likely that adapted variants preexist in the population even before the selective pressure has changed [9, 10] .
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