Author: Hermesh, Tamar; Moltedo, Bruno; López, Carolina B.; Moran, Thomas M.
Title: Buying Time—The Immune System Determinants of the Incubation Period to Respiratory Viruses Document date: 2010_11_18
ID: 0yqv2osb_30
Snippet: Viruses have evolved to inhibit IFN induction in a number of ways; the many functions of the influenza A non-structural protein 1 (NS1) have been recently reviewed [60] . Influenza NS1 inhibits RIG-I and IPS-1 signaling by forming a complex with RIG-I and ssRNA [34, [61] [62] [63] . This explains the inhibition of IRF-3, NFκB, and c-Jun/ATF-2 activation observed upon infection with influenza viruses [64] [65] [66] . In addition, influenza A NS1 .....
Document: Viruses have evolved to inhibit IFN induction in a number of ways; the many functions of the influenza A non-structural protein 1 (NS1) have been recently reviewed [60] . Influenza NS1 inhibits RIG-I and IPS-1 signaling by forming a complex with RIG-I and ssRNA [34, [61] [62] [63] . This explains the inhibition of IRF-3, NFκB, and c-Jun/ATF-2 activation observed upon infection with influenza viruses [64] [65] [66] . In addition, influenza A NS1 blocks virus detection by binding to dsRNA, thereby masking it from detection by RIG-I [67, 68] . Influenza NS1 also inhibits the cellular response by interfering with the processing and export of cellular mRNA [69, 70] .
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