Author: Wilkins, Jordan; Zheng, Yi-Min; Yu, Jingyou; Liang, Chen; Liu, Shan-Lu
Title: Nonhuman Primate IFITM Proteins Are Potent Inhibitors of HIV and SIV Document date: 2016_6_3
ID: 1m1woscb_42
Snippet: In general, restriction factors are characterized with antiviral activity, are interferon inducible, targeted by viral antagonists, and undergo positive selection. Positive selection of restriction factors results from continual virus-host competition that occurs during infection. This effect is described by the Red Queen hypothesis, which results in an excess of non-synonymous mutations over time in both the virus and host restriction factors im.....
Document: In general, restriction factors are characterized with antiviral activity, are interferon inducible, targeted by viral antagonists, and undergo positive selection. Positive selection of restriction factors results from continual virus-host competition that occurs during infection. This effect is described by the Red Queen hypothesis, which results in an excess of non-synonymous mutations over time in both the virus and host restriction factors improving their overall fitness (positive selection). For example, the restriction factors TRIM5α, Tehterin, APOBEC3G, SAMHD1, and Viperin are all interferon inducible, restrict lentiviruses, and have undergone positive selection as a result of competing with viral antagonists [60] [61] [62] [63] [64] .
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