Author: Wysocki, Jan; Schulze, Arndt; Batlle, Daniel
Title: Novel Variants of Angiotensin Converting Enzyme-2 of Shorter Molecular Size to Target the Kidney Renin Angiotensin System Document date: 2019_12_17
ID: 0vozochc_16
Snippet: The pharmacokinetic profiles of mouse rACE2 1-619 and 1-605 were assessed in Balb/c mice as compared to those of native mouse rACE2 1-740. The mice received a single i.v. or i.p. injection of each purified small rACE2 variant at a dose of 1 µg/g body weight. Blood samples were collected by tail bleeding either before or at a number of indicated time points after injection. Blood samples collected in heparinized capillaries were left undisturbed .....
Document: The pharmacokinetic profiles of mouse rACE2 1-619 and 1-605 were assessed in Balb/c mice as compared to those of native mouse rACE2 1-740. The mice received a single i.v. or i.p. injection of each purified small rACE2 variant at a dose of 1 µg/g body weight. Blood samples were collected by tail bleeding either before or at a number of indicated time points after injection. Blood samples collected in heparinized capillaries were left undisturbed on ice, and plasma was isolated by centrifugation at 1850 g for 10 min at 4 • C. Mca-APK(Dnp) substrate (Bachem, Bubendorf, BL, Switzerland), PA) was used to measure ACE2 enzyme activity in plasma. The half-life (t 1/2 ), area under the plasma activity time curve and mean residence time of rACE2 species were calculated [15] using Prism 8 software (GraphPad, La Jolla, CA, USA).
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