Author: Li, Xiao-Bo; Wang, Shu-Qing; Xu, Wei-Ren; Wang, Run-Ling; Chou, Kuo-Chen
Title: Novel Inhibitor Design for Hemagglutinin against H1N1 Influenza Virus by Core Hopping Method Document date: 2011_11_30
ID: 16syz1o7_3
Snippet: Sialic acid (SA) as a natural ligand combines with both of the glycoproteins (HA and NA) and located at the membrane of host cell, which is the basis of heme-agglutination when viruses are mixed with blood cells and entry of the virus into cells of the upper respiratory tract [11, 12] . According to the mutagenic analysis the residues of both HA1 and NA binding sites are quite conserved for most influenza A strains [13, 14] ......
Document: Sialic acid (SA) as a natural ligand combines with both of the glycoproteins (HA and NA) and located at the membrane of host cell, which is the basis of heme-agglutination when viruses are mixed with blood cells and entry of the virus into cells of the upper respiratory tract [11, 12] . According to the mutagenic analysis the residues of both HA1 and NA binding sites are quite conserved for most influenza A strains [13, 14] .
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