Selected article for: "activity amplification and acute kidney injury"
Author: Wysocki, Jan; Schulze, Arndt; Batlle, Daniel
Title: Novel Variants of Angiotensin Converting Enzyme-2 of Shorter Molecular Size to Target the Kidney Renin Angiotensin System
  • Document date: 2019_12_17
    • ID: 0vozochc_50
    Snippet: In summary, we have developed short ACE2 variants with improved pharmacokinetic properties, as compared to the native rACE2. The short ACE2 protein variants, unlike the intact ACE2 protein, undergo glomerular filtration and tubular uptake. The kidney uptake of enzymatically active short ACE2 variants can enhance the local formation of Ang (1-7) from Ang II. The administration of active small ACE2 variants offers therapeutic potential in the preve.....
    Document: In summary, we have developed short ACE2 variants with improved pharmacokinetic properties, as compared to the native rACE2. The short ACE2 protein variants, unlike the intact ACE2 protein, undergo glomerular filtration and tubular uptake. The kidney uptake of enzymatically active short ACE2 variants can enhance the local formation of Ang (1-7) from Ang II. The administration of active small ACE2 variants offers therapeutic potential in the prevention and treatment of acute kidney injury by directly reducing kidney RAS overactivity while retaining their systemic effect on ACE2 activity amplification.

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