Author: Marriott, Andrew S.; Vasieva, Olga; Fang, Yongxiang; Copeland, Nikki A.; McLennan, Alexander G.; Jones, Nigel J.
Title: NUDT2 Disruption Elevates Diadenosine Tetraphosphate (Ap(4)A) and Down-Regulates Immune Response and Cancer Promotion Genes Document date: 2016_5_4
ID: 0ozzbp85_34
Snippet: 1. GFRA1 encodes a receptor for glial cell line-derived neurotrophic factor (GDNF) and is classified by edgeR as the most strongly down-regulated gene in the dataset (3221-fold). The proliferation of prostate cancer cells and their resistance to genotoxic treatment correlate directly with the level of GFRA1 expression [80] . It is also up-regulated in breast carcinoma [81] while GFRA1 released by cells can promote cancer cell migration and invasi.....
Document: 1. GFRA1 encodes a receptor for glial cell line-derived neurotrophic factor (GDNF) and is classified by edgeR as the most strongly down-regulated gene in the dataset (3221-fold). The proliferation of prostate cancer cells and their resistance to genotoxic treatment correlate directly with the level of GFRA1 expression [80] . It is also up-regulated in breast carcinoma [81] while GFRA1 released by cells can promote cancer cell migration and invasion [82] .
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