Author: Marriott, Andrew S.; Vasieva, Olga; Fang, Yongxiang; Copeland, Nikki A.; McLennan, Alexander G.; Jones, Nigel J.
Title: NUDT2 Disruption Elevates Diadenosine Tetraphosphate (Ap(4)A) and Down-Regulates Immune Response and Cancer Promotion Genes Document date: 2016_5_4
ID: 0ozzbp85_44
Snippet: 12. Overexpression of NKD2, a negative regulator of Wnt signaling, in metastatic osteosarcoma and breast carcinoma significantly reduces tumor growth and metastasis in vivo and decreases cell proliferation, migration and invasion in vitro, while down-regulation has the opposite effect [100, 101] . It is up-regulated 19-fold. 13 . The leukemia inhibitory factor receptor LIFR has been shown to act as a suppressor of metastasis in hepatocellular car.....
Document: 12. Overexpression of NKD2, a negative regulator of Wnt signaling, in metastatic osteosarcoma and breast carcinoma significantly reduces tumor growth and metastasis in vivo and decreases cell proliferation, migration and invasion in vitro, while down-regulation has the opposite effect [100, 101] . It is up-regulated 19-fold. 13 . The leukemia inhibitory factor receptor LIFR has been shown to act as a suppressor of metastasis in hepatocellular carcinoma [102] . Increased LIFR activity has also been correlated with a reduction in the pool of breast cancer stem cells [103] . It is up-regulated 11-fold.
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