Author: Marriott, Andrew S.; Vasieva, Olga; Fang, Yongxiang; Copeland, Nikki A.; McLennan, Alexander G.; Jones, Nigel J.
Title: NUDT2 Disruption Elevates Diadenosine Tetraphosphate (Ap(4)A) and Down-Regulates Immune Response and Cancer Promotion Genes Document date: 2016_5_4
ID: 0ozzbp85_60
Snippet: Protein kinases and other ATP-dependent factors. By virtue of its structural similarity to ATP, Ap 4 A might regulate transcription by inhibition of protein kinases, of which there are over 500 in the human genome [148] . Ap 4 A has been shown to inhibit v-Src [26] , casein kinase II [27] and protein kinase C [28] . These and many other protein kinases, some of which might be particularly sensitive to Ap 4 A, are known to regulate transcription f.....
Document: Protein kinases and other ATP-dependent factors. By virtue of its structural similarity to ATP, Ap 4 A might regulate transcription by inhibition of protein kinases, of which there are over 500 in the human genome [148] . Ap 4 A has been shown to inhibit v-Src [26] , casein kinase II [27] and protein kinase C [28] . These and many other protein kinases, some of which might be particularly sensitive to Ap 4 A, are known to regulate transcription factor activity directly or indirectly and several examples of potential targets feature in Figs 4-6. In the absence of evidence strongly favoring alternative possibilities, protein kinases and other ATP-dependent regulatory factors such as phosphoinositide kinases, chaperones and ABC transporters must be regarded as likely targets for Ap 4 A that will require future investigation.
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