Author: Dai, Xiaofeng; Hakizimana, Olivier; Zhang, Xuanhao; Kaushik, Aman Chandra; Zhang, Jianying
Title: Orchestrated efforts on host network hijacking: Processes governing virus replication Document date: 2020_2_12
ID: 1dc46btc_16
Snippet: Apoptosis triggered in non-infected inflammatory or immune cells could paralyze host's innate and adaptive defense systems to foster a favorable environment for the progression of viruses and their progenies ( Figure 2 ) [54] . It was observed that T cells isolated from HIVinfected individuals underwent spontaneous apoptosis. Two mechanisms were proposed, i.e. uninfected T cells are capped with CD4 molecules by the HIV-Env proteins from the infec.....
Document: Apoptosis triggered in non-infected inflammatory or immune cells could paralyze host's innate and adaptive defense systems to foster a favorable environment for the progression of viruses and their progenies ( Figure 2 ) [54] . It was observed that T cells isolated from HIVinfected individuals underwent spontaneous apoptosis. Two mechanisms were proposed, i.e. uninfected T cells are capped with CD4 molecules by the HIV-Env proteins from the infected macrophages and thus undergo apoptosis [57] , or cell death is triggered via the bystander effect mediated by Fas-FasL interactions [58 59,] .
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