Author: Marriott, Andrew S.; Vasieva, Olga; Fang, Yongxiang; Copeland, Nikki A.; McLennan, Alexander G.; Jones, Nigel J.
Title: NUDT2 Disruption Elevates Diadenosine Tetraphosphate (Ap(4)A) and Down-Regulates Immune Response and Cancer Promotion Genes Document date: 2016_5_4
ID: 0ozzbp85_48
Snippet: If the above set of prominent DEGs were expressed and responded in the same way to increased Ap 4 A in carcinomas, the overwhelming net effect could be the strong suppression of tumor growth and, particularly, metastasis. Furthermore, as indicated previously, IDO1 and several other enzymes of Trp catabolism are strongly down-regulated in NuKO cells. Increased IDO1 expression is a characteristic of many cancer cells and assists them in avoiding cl.....
Document: If the above set of prominent DEGs were expressed and responded in the same way to increased Ap 4 A in carcinomas, the overwhelming net effect could be the strong suppression of tumor growth and, particularly, metastasis. Furthermore, as indicated previously, IDO1 and several other enzymes of Trp catabolism are strongly down-regulated in NuKO cells. Increased IDO1 expression is a characteristic of many cancer cells and assists them in avoiding clearance by the immune system, with the level of expression often correlating with poor prognosis [72, 128] and so inhibitors of IDO1 have been considered as novel immunotherapeutic adjuvants to conventional anti-cancer drugs [129, 130] .
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