Author: Vega, Vinsensius B; Ruan, Yijun; Liu, Jianjun; Lee, Wah Heng; Wei, Chia Lin; Se-Thoe, Su Yun; Tang, Kin Fai; Zhang, Tao; Kolatkar, Prasanna R; Ooi, Eng Eong; Ling, Ai Ee; Stanton, Lawrence W; Long, Philip M; Liu, Edison T
Title: Mutational dynamics of the SARS coronavirus in cell culture and human populations isolated in 2003 Document date: 2004_9_6
ID: 0gmtnkbh_21
Snippet: Singapore encountered an unusual incident where a stable lab SARS-CoV isolate commonly used for in vitro experimentation accidentally infected a laboratory worker [10] . We sequenced both the originating laboratory isolate (SIN_WNV; see Table S1 ) and the viral sample directly from the patient's sputum (SIN0409; see Table S2 ) and found no sequence difference between the two viruses. This reconfirms that the mutation rate from a single point sour.....
Document: Singapore encountered an unusual incident where a stable lab SARS-CoV isolate commonly used for in vitro experimentation accidentally infected a laboratory worker [10] . We sequenced both the originating laboratory isolate (SIN_WNV; see Table S1 ) and the viral sample directly from the patient's sputum (SIN0409; see Table S2 ) and found no sequence difference between the two viruses. This reconfirms that the mutation rate from a single point source of virus has a low mutation rate when expanded during human infection.
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