Author: Perra, Léa; Balloy, Viviane; Foussignière, Tobias; Moissenet, Didier; Petat, Hortense; Mungrue, Imran N.; Touqui, Lhousseine; Corvol, Harriet; Chignard, Michel; Guillot, Loic
Title: CHAC1 Is Differentially Expressed in Normal and Cystic Fibrosis Bronchial Epithelial Cells and Regulates the Inflammatory Response Induced by Pseudomonas aeruginosa Document date: 2018_11_29
ID: 10fe70kl_3
Snippet: The lung epithelium plays an essential role in the fight against infections by orchestrating innate immunity (8) . Lung epithelial cells are sufficient to generate an innate protective immune response in mice infected with Pa (9). In CF, establishment of chronic pulmonary infection with Pa is linked to alterations in epithelial cell responses, which do not allow establishment of an adequate defense system (4) . Previously, we showed that this res.....
Document: The lung epithelium plays an essential role in the fight against infections by orchestrating innate immunity (8) . Lung epithelial cells are sufficient to generate an innate protective immune response in mice infected with Pa (9). In CF, establishment of chronic pulmonary infection with Pa is linked to alterations in epithelial cell responses, which do not allow establishment of an adequate defense system (4) . Previously, we showed that this response was indeed different by comparative analysis of the transcriptomic signatures of primary CF and non-CF bronchial epithelial cells during Pa infection (10) . We identified several up-and downregulated mRNAs in CF cells compared with those in non-CF cells, suggesting that these genes may be involved in the exacerbated inflammatory response to Pa found in CF patients. Among these dysregulated mRNAs, ChaC glutathione-specific γ-glutamylcyclotransferase 1 (CHAC1) showed dramatically differential expression between non-CF and CF cells both at baseline and after Pa infection.
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