Author: Dai, Xiaofeng; Hakizimana, Olivier; Zhang, Xuanhao; Kaushik, Aman Chandra; Zhang, Jianying
Title: Orchestrated efforts on host network hijacking: Processes governing virus replication Document date: 2020_2_12
ID: 1dc46btc_42
Snippet: Viruses can target and navigate multiple cell networks during and after cell infection. For instance, adenovirus particles exert targeted control of a well-defined neighborhood of networks including endocytosis, autophagy, and microtubule trafficking by coupling several processes to a single protein, protein VI [136] . The five processes we reviewed here do not work alone but orchestrate synergistically to rewire cells fate toward a state favorab.....
Document: Viruses can target and navigate multiple cell networks during and after cell infection. For instance, adenovirus particles exert targeted control of a well-defined neighborhood of networks including endocytosis, autophagy, and microtubule trafficking by coupling several processes to a single protein, protein VI [136] . The five processes we reviewed here do not work alone but orchestrate synergistically to rewire cells fate toward a state favorable for virus replication ( Figure 6 ). Autophagy and programmed cell death are cell survival programs; immune response is a cell defense program; cell cycle alteration and lipid metabolic reprogramming are adaptations on cell housekeeping physiologies. There is an established two-way dialogue among these identified processes, which collectively orchestrate virus replication and determine the fates of invading viruses and host cells.
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