Author: Dai, Xiaofeng; Hakizimana, Olivier; Zhang, Xuanhao; Kaushik, Aman Chandra; Zhang, Jianying
Title: Orchestrated efforts on host network hijacking: Processes governing virus replication Document date: 2020_2_12
ID: 1dc46btc_3
Snippet: Cell-based approaches for vaccine production use animal cells for vaccine manufacturing, which have more elasticity (regarding the diversity of virus strains feasible for production) than approaches utilizing embryonic eggs [7] . Virus entry and replication processes are orchestrated by a complex network of interactions [8] [9] [10] [11] . Murray et al. demonstrated the feasibility of creating an enhanced universal cell line by experimenting with.....
Document: Cell-based approaches for vaccine production use animal cells for vaccine manufacturing, which have more elasticity (regarding the diversity of virus strains feasible for production) than approaches utilizing embryonic eggs [7] . Virus entry and replication processes are orchestrated by a complex network of interactions [8] [9] [10] [11] . Murray et al. demonstrated the feasibility of creating an enhanced universal cell line by experimenting with a range of viruses replicating in Vero or Hep-2 cells, and found that knocking down host genes such as CNTD2, COQ9, GCGR, NDUFA9, NEU2, PYCR1, SEC16G, SVOPL, ZFYVE9, ZNF205 could result in 2-fold to over 1000-fold enhanced replication among 12 tested virus strains [12] . Therefore, it could significantly reduce the cost and complexity of the vaccine production if a universal cell line feasible for the rapid replication of multiple viruses was available where apprehending how viruses hijack host networks to survive is a prerequisite.
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