Author: Dai, Xiaofeng; Hakizimana, Olivier; Zhang, Xuanhao; Kaushik, Aman Chandra; Zhang, Jianying
Title: Orchestrated efforts on host network hijacking: Processes governing virus replication Document date: 2020_2_12
ID: 1dc46btc_47
Snippet: Viruses have evolved various approaches to rewire "autophagy", "programmed cell death", "immune response", "cell cycle alteration", and "lipid metabolic reprogramming" toward a favorable state for their survival and replication. The clinical and industrial values of these processes are double-sided. On one hand, developing drugs targeting one or several pivotal genes/proteins that foster the five overlapping cellular processes after viral infecti.....
Document: Viruses have evolved various approaches to rewire "autophagy", "programmed cell death", "immune response", "cell cycle alteration", and "lipid metabolic reprogramming" toward a favorable state for their survival and replication. The clinical and industrial values of these processes are double-sided. On one hand, developing drugs targeting one or several pivotal genes/proteins that foster the five overlapping cellular processes after viral infection (such as protein VI of adenovirus [136] ) may enhance and/or create synergistic effect with the current treatment modalities of virus-related diseases. On the other hand, endogenously or exogenously modulating one or multiple processes may increase the yield of viral particles that become vaccines once inactivated. Strategies modulating these identified processes are not restricted to any particular type of viruses given their unanimous presence, which reduces the clinical treatment complexity and industrial developmental cost.
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