Nanoparticles for Signaling in Biodiagnosis and Treatment of Infectious Diseases

Colino, Clara I.; Millán, Carmen Gutiérrez; Lanao, José M.

The lactonases belong to the metallo β lactamase superfamily. They inactivate AHL by hydrolyzing the ester bond, causing the opening of the homoserinelactone ring Acylases break the AHL amide, rendering the fatty acid and the homoserinelactone ring, products that do not show any activity [174, 175] . As the AHL of different bacterial species maintain the homoserinelactone ring, lactonases are active for all of them [176, 177] . Acylase activity depends on AHL fatty acid substitutes or chain length, which show variations between species [178] [179] [180] . Oxidoreductases are the most recently discovered AHL enzymes inactivating group. They modify but do not break AHL, transforming oxo-AHL into the corresponding hidroxyAHL. This can affect AHL receptor binding [181, 182] .