Author: Colino, Clara I.; Millán, Carmen Gutiérrez; Lanao, José M.
Title: Nanoparticles for Signaling in Biodiagnosis and Treatment of Infectious Diseases Document date: 2018_5_31
ID: 1bxwb2hj_151
Snippet: Also, several niosome formulations, including tobramycin and bismuth-ethanedithiol, were evaluated both alone and in combination as drug delivery systems with regards to quorum sensing and biofilm formation in various strains of Pseudomonas aeruginosa. The composition of niosomes included: Span 40, Tween 40 and 30% cholesterol. The incorporation in niosomes reduced the minimum inhibitory concentration (MIC) of formulations including tobramycin in.....
Document: Also, several niosome formulations, including tobramycin and bismuth-ethanedithiol, were evaluated both alone and in combination as drug delivery systems with regards to quorum sensing and biofilm formation in various strains of Pseudomonas aeruginosa. The composition of niosomes included: Span 40, Tween 40 and 30% cholesterol. The incorporation in niosomes reduced the minimum inhibitory concentration (MIC) of formulations including tobramycin in comparison with the non-encapsulated ones. This has been attributed to an enhanced penetration of the antibiotic in the cell [210] . Furthermore, 1:2 MIC and 1:4 MIC concentrations of the free and niosomal bismuth-ethanedithiol tobramycin combinations were the most effective, inhibiting biofilm formation by over 80%. These two formulations were also able to inhibit AHL production [211] .
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