Author: Melnik, Lilia I; Garry, Robert F; Morris, Cindy A
Title: Peptide inhibition of human cytomegalovirus infection Document date: 2011_2_22
ID: 0p6x4lwx_22
Snippet: Enfurvitide, a 36-amino acid peptide also known as Fuzeon works by inhibiting the structural rearrangement of HIV-1 gp41 to block the fusion of HIV-1 virions with their target cell membrane. Brennan-Benson et al. showed that Fuzeon prevents vertical transmission of HIV-1 in pregnancy, but does not cross the placenta [55] . We have shown that some peptides are effective at preventing HCMV infection. Those lead peptides will be studied further and .....
Document: Enfurvitide, a 36-amino acid peptide also known as Fuzeon works by inhibiting the structural rearrangement of HIV-1 gp41 to block the fusion of HIV-1 virions with their target cell membrane. Brennan-Benson et al. showed that Fuzeon prevents vertical transmission of HIV-1 in pregnancy, but does not cross the placenta [55] . We have shown that some peptides are effective at preventing HCMV infection. Those lead peptides will be studied further and modified to increase their efficacy, solubility and delivery.
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