Author: Melnik, Lilia I; Garry, Robert F; Morris, Cindy A
Title: Peptide inhibition of human cytomegalovirus infection Document date: 2011_2_22
ID: 0p6x4lwx_5
Snippet: The lack of a successful HCMV vaccine as well as the toxicity and drug-induced resistance associated with current therapeutics for HCMV indicate that this virus continues to pose a significant public health problem. Current treatments for HCMV disease target viral replication and can fail due to the emergence of drug-resistant virus variants and induction of adverse effects. Hence, a new approach in drug design against HCMV is required [26, 27] ......
Document: The lack of a successful HCMV vaccine as well as the toxicity and drug-induced resistance associated with current therapeutics for HCMV indicate that this virus continues to pose a significant public health problem. Current treatments for HCMV disease target viral replication and can fail due to the emergence of drug-resistant virus variants and induction of adverse effects. Hence, a new approach in drug design against HCMV is required [26, 27] . Since HCMV and other herpesviruses establish a lifelong latency in humans, antiviral therapy that inhibits viral entry may serve as an alternative to the already existing and inadequate therapeutic agents. Here, we report the design, development and characterization of peptides that specifically inhibit viral infection and/or entry as a novel approach to prevent HCMV infection.
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