Selected article for: "processing virus particle assembly and virus assembly"
Author: Pan, Yen-Yu; Wang, Shiu-Mei; Huang, Kuo-Jung; Chiang, Chien-Cheng; Wang, Chin-Tien
Title: Placement of Leucine Zipper Motifs at the Carboxyl Terminus of HIV-1 Protease Significantly Reduces Virion Production
  • Document date: 2012_3_1
    • ID: 09locmnw_25
    Snippet: Pettit et al. [41] have demonstrated that inactivated PR dimer interface mutations can be compensated for to some extent by extra PR sequences in the Gag-Pol context. Altered PR dimerization kinetics or activity has been identified in several studies of PR-containing C-or N-terminal extensions into Gag-Pol [21, 23, 24, 38, 40, 43, 51, 52] . In most cases, it is not feasible to assay the impacts of these constructs on virus assembly or PR-mediated.....
    Document: Pettit et al. [41] have demonstrated that inactivated PR dimer interface mutations can be compensated for to some extent by extra PR sequences in the Gag-Pol context. Altered PR dimerization kinetics or activity has been identified in several studies of PR-containing C-or N-terminal extensions into Gag-Pol [21, 23, 24, 38, 40, 43, 51, 52] . In most cases, it is not feasible to assay the impacts of these constructs on virus assembly or PR-mediated virus maturation, due to overlapping gag and pol reading frames. Our approach provides a convenient system for analyzing the impacts of mutations on PR dimer interactions by assessing virus particle assembly and processing. Studies are underway to determine if LZ sufficiently compensates for the inactivation of PR dimer interface mutations.

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