Author: Chuck, Chi-Pang; Chow, Hak-Fun; Wan, David Chi-Cheong; Wong, Kam-Bo
Title: Profiling of Substrate Specificities of 3C-Like Proteases from Group 1, 2a, 2b, and 3 Coronaviruses Document date: 2011_11_2
ID: 0vu7bobr_8
Snippet: We then tested if the relative activities of 3CL pro from any CoV strains were significantly different from the other by analysis of variance. Substitutions that resulted in significantly higher relative activities (p,0.001) were indicated as filled symbol in Figure 1 . IBV 3CL pro (Figure 1 , triangles) was the most efficient in cleaving A4P and A4F with relative activities of 1.0960.24 and 0.5860.14, respectively, while SARS 3CL pro (Figure 1 ,.....
Document: We then tested if the relative activities of 3CL pro from any CoV strains were significantly different from the other by analysis of variance. Substitutions that resulted in significantly higher relative activities (p,0.001) were indicated as filled symbol in Figure 1 . IBV 3CL pro (Figure 1 , triangles) was the most efficient in cleaving A4P and A4F with relative activities of 1.0960.24 and 0.5860.14, respectively, while SARS 3CL pro (Figure 1 , diamonds) preferred A4V with relative activity of 1.3960.19. HCoV-OC43 3CL pro (Figure 1 , squares) appeared to be the most versatile in accepting substitutions at P1 and P2 positions, and could cleave Q1H, Q1M, L2M and L2C, significantly better than 3CL pro from other strains. No significant differences were observed for other substitutions, suggesting that 3CL pro from different CoVs shares many similarities in substrate preferences.
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