Selected article for: "admission department and logistic regression"
Author: O’Connell, Grant C.; Treadway, Madison B.; Petrone, Ashley B.; Tennant, Connie S.; Lucke-Wold, Noelle; Chantler, Paul D.; Barr, Taura L.
Title: Peripheral blood AKAP7 expression as an early marker for lymphocyte-mediated post-stroke blood brain barrier disruption
  • Document date: 2017_4_26
    • ID: 1ey6ie95_1
    Snippet: Early peripheral blood expression of AKAP7 is associated with the development of post-stroke BBB disruption. In order to determine the relationships between the expression levels of the 16 stroke-associated candidate genes and post-stroke BBB disruption, we first recruited a modestly sized discovery cohort consisting of 27 acute ischemic stroke (AIS) patients. Peripheral whole blood samples were obtained at emergency department admission and tran.....
    Document: Early peripheral blood expression of AKAP7 is associated with the development of post-stroke BBB disruption. In order to determine the relationships between the expression levels of the 16 stroke-associated candidate genes and post-stroke BBB disruption, we first recruited a modestly sized discovery cohort consisting of 27 acute ischemic stroke (AIS) patients. Peripheral whole blood samples were obtained at emergency department admission and transcriptional profiling was performed via microarray. BBB permeability was assessed via level of HARM (none, mild, moderate, or severe) on perfusion-weighted imaging at 24 hour follow up (Fig. 1) . We then employed bias-reduced logistic regression using forward stepwise variable selection to determine whether early expression levels of any the 16 candidate genes were predictive for the development of poststroke severe HARM.

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