Selected article for: "international license and low level"
Author: Kun Sun; Liuqi Gu; Li Ma; Yunfeng Duan
Title: Atlas of ACE2 gene expression in mammals reveals novel insights in transmission of SARS-Cov-2
  • Document date: 2020_3_31
    • ID: 89sg0cpk_33
    Snippet: Our analyses showed that mammalian ACE2 genes are highly conserved across lineages and exhibit broad expression patterns. However, tissue-specific expression profiles varied from species to species, suggesting certain mammals may be the hosts of SARS-CoV-2, i.e., carriers without significant symptoms. Compared to humans, other mammals examined in this study either don't express ACE2 in their testes, or at a low level. On the contrary, among non-h.....
    Document: Our analyses showed that mammalian ACE2 genes are highly conserved across lineages and exhibit broad expression patterns. However, tissue-specific expression profiles varied from species to species, suggesting certain mammals may be the hosts of SARS-CoV-2, i.e., carriers without significant symptoms. Compared to humans, other mammals examined in this study either don't express ACE2 in their testes, or at a low level. On the contrary, among non-human species kidney was almost always the tissue with highest ACE2 expression. Meanwhile, it is worth noting that mouse is a . CC-BY 4.0 International license author/funder. It is made available under a The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.03.30.015644 doi: bioRxiv preprint common model species for many human medical studies, including COVID-19.

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