Author: Bohmwald, Karen; Gálvez, Nicolás M. S.; Ríos, Mariana; Kalergis, Alexis M.
Title: Neurologic Alterations Due to Respiratory Virus Infections Document date: 2018_10_26
ID: 0rlotyz3_58
Snippet: Several ways to achieve CNS have been described, including transneural and hematogenous pathways. However, the specific mechanisms responsible for dissemination of each of these viruses with neurotropic capacities into the CNS, have not been thoroughly characterized yet. For instance, hRSV has been reported to reach CNS via the hematogenous pathway, although other routes cannot be discarded entirely. IV can reach the brain via the transneural rou.....
Document: Several ways to achieve CNS have been described, including transneural and hematogenous pathways. However, the specific mechanisms responsible for dissemination of each of these viruses with neurotropic capacities into the CNS, have not been thoroughly characterized yet. For instance, hRSV has been reported to reach CNS via the hematogenous pathway, although other routes cannot be discarded entirely. IV can reach the brain via the transneural route, mainly by retrograde axonal transport, reaching first vagal and trigeminal nerves. Likewise, CoV has been described to reach the brain via olfactory bulb, spreading from this point onward into the CNS and the periphery. Since hMPV is an emerging virus, no studies have been performed regarding its capacity to reach CNS, so further data for this virus is required.
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