Author: Hsu, Shih-Hsien; Yeh, Ming-Lun; Wang, Shen-Nien
Title: New Insights in Recurrent HCV Infection after Liver Transplantation Document date: 2013_4_23
ID: 0hbeso65_43
Snippet: Interfering with HCV entry into the hepatocytes holds great promises for the development of novel drugs. Several potential targets are suggested: (1) blocking virus-target cell interaction during attachment and binding; (2) interfering with postbinding events and (3) interfering with viral fusion. Various modalities may be adopted as HCV entry inhibitors: neutralizing antibodies for HCV envelope glycoproteins, blocking antibodies specific for hos.....
Document: Interfering with HCV entry into the hepatocytes holds great promises for the development of novel drugs. Several potential targets are suggested: (1) blocking virus-target cell interaction during attachment and binding; (2) interfering with postbinding events and (3) interfering with viral fusion. Various modalities may be adopted as HCV entry inhibitors: neutralizing antibodies for HCV envelope glycoproteins, blocking antibodies specific for host factors, and small molecular compounds against host factors or viral proteins.
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