Selected article for: "activity expression and cell death"
Author: Manandhar, Bandana; Paudel, Pradeep; Seong, Su Hui; Jung, Hyun Ah; Choi, Jae Sue
Title: Characterizing Eckol as a Therapeutic Aid: A Systematic Review
  • Document date: 2019_6_18
    • ID: 0dpv85od_112
    Snippet: Manganese superoxide dismutase (MnSOD) is an antioxidant mitochondrial enzyme in exhibiting cytoprotective effects against oxidative stress. This enzyme is used as a marker to evaluate the antioxidant properties of phytochemicals. As an antioxidant, eckol at 10 µg/mL recovered MnSOD expression and activity that had been decreased by 600 µM hydrogen peroxide (H 2 O 2 ). Through the pathway of phosphorylated AMP-activated protein kinase/forkhead .....
    Document: Manganese superoxide dismutase (MnSOD) is an antioxidant mitochondrial enzyme in exhibiting cytoprotective effects against oxidative stress. This enzyme is used as a marker to evaluate the antioxidant properties of phytochemicals. As an antioxidant, eckol at 10 µg/mL recovered MnSOD expression and activity that had been decreased by 600 µM hydrogen peroxide (H 2 O 2 ). Through the pathway of phosphorylated AMP-activated protein kinase/forkhead box O3a (AMPK/FoxO3a), the MnSOD expression was induced by eckol. Eckol-stimulated MnSOD expression was reduced by 10-50 nM of specific silencing RNAs (siRNAs) against FoxO3a and AMPK. Additionally, the cytoprotective activity of eckol against H 2 O 2 -provoked cell death was reduced by diethyldithiocarbamate (a MnSOD inhibitor). Thus, by activating the AMPK/FoxO3a-mediated induction of MnSOD, eckol protected the cells against the oxidative stress in mitochondria [44] .

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