Author: van Zuylen, Wendy J.; Doyon, Priscilla; Clément, Jean-François; Khan, Kashif Aziz; D'Ambrosio, Lisa M.; Dô, Florence; St-Amant-Verret, Myriam; Wissanji, Tasheen; Emery, Gregory; Gingras, Anne-Claude; Meloche, Sylvain; Servant, Marc J.
Title: Proteomic Profiling of the TRAF3 Interactome Network Reveals a New Role for the ER-to-Golgi Transport Compartments in Innate Immunity Document date: 2012_7_5
ID: 1m5dbwjv_28
Snippet: Gene disruption strategies have revealed that TRAF3 plays a major role in the type I IFN response [12, 13] . However, how TRAF3 assembles into functional signalling complexes is still not fully understood. In general, TRAF3 is thought to reside in the cytosol and translocate to surface membrane receptors upon engagement of CD40 or other TNFR family members [54] . Akin to its role in MyD88-dependent cytokine production and TRIFdependent type I IFN.....
Document: Gene disruption strategies have revealed that TRAF3 plays a major role in the type I IFN response [12, 13] . However, how TRAF3 assembles into functional signalling complexes is still not fully understood. In general, TRAF3 is thought to reside in the cytosol and translocate to surface membrane receptors upon engagement of CD40 or other TNFR family members [54] . Akin to its role in MyD88-dependent cytokine production and TRIFdependent type I IFN production [55] , TRAF3 conceivably also has the capacity to associate with endosomal compartments enriched in TLR3, TLR4, TLR7, TLR8 and TLR9 receptors [56] . Additionally, upon RLH activation TRAF3 interacts with MAVS and TRADD to trigger IRF-3 phosphorylation through the adaptor molecule TANK and the IKK-related kinases TBK1 and IKKi [20, 21] . However, how TRAF3 associates with MAVS upon RLH activation remains unanswered.
Search related documents:
Co phrase search for related documents- adaptor molecule and endosomal compartment: 1
- adaptor molecule and ifn production: 1, 2, 3, 4, 5, 6, 7
- adaptor molecule and ifn response: 1, 2, 3, 4, 5
- adaptor molecule and major role: 1
- adaptor molecule and phosphorylation trigger: 1
- cytokine production and endosomal compartment: 1
- cytokine production and fully understand: 1
- cytokine production and Gene disruption: 1
- cytokine production and ifn production: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- cytokine production and ifn response: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24
- cytokine production and major role: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14
- cytokine production and membrane receptor: 1, 2
- cytokine production and signalling complex: 1
- endosomal compartment and major role: 1
- endosomal compartment and membrane receptor: 1
- endosomal compartment and membrane receptor surface: 1
- fully understand and ifn response: 1, 2
- fully understand and membrane receptor: 1
- fully understand and membrane receptor surface: 1
Co phrase search for related documents, hyperlinks ordered by date