Author: Wilkins, Jordan; Zheng, Yi-Min; Yu, Jingyou; Liang, Chen; Liu, Shan-Lu
Title: Nonhuman Primate IFITM Proteins Are Potent Inhibitors of HIV and SIV Document date: 2016_6_3
ID: 1m1woscb_3
Snippet: HIV-1 and HIV-2 are the results of zoonotic transmission of SIV into humans from chimpanzee and sooty mangabey, respectively [39, 40] . Adaptation into new hosts often requires viruses to evolve countermeasures to evade new host defenses. For example, TRIM5α from rhesus monkey (TRIM5αrh) is highly effective at restricting HIV-1 [5] . However, TRIM5αrh does not restrict viruses that naturally infect Old World monkeys (SIVmac). These observation.....
Document: HIV-1 and HIV-2 are the results of zoonotic transmission of SIV into humans from chimpanzee and sooty mangabey, respectively [39, 40] . Adaptation into new hosts often requires viruses to evolve countermeasures to evade new host defenses. For example, TRIM5α from rhesus monkey (TRIM5αrh) is highly effective at restricting HIV-1 [5] . However, TRIM5αrh does not restrict viruses that naturally infect Old World monkeys (SIVmac). These observations were attributed to changes in the sequence of viral capsid from SIV to HIV [5] . Similarly, human Tetherin is less effective restricting HIV when compared to that of SIV and vice versa [41] . The decreased inhibitory effects of human TRIM5α and Tetherin on HIV-1 account for efficient spread and pathogenesis of HIV-1 in humans [42] .
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