Author: Wilkins, Jordan; Zheng, Yi-Min; Yu, Jingyou; Liang, Chen; Liu, Shan-Lu
Title: Nonhuman Primate IFITM Proteins Are Potent Inhibitors of HIV and SIV Document date: 2016_6_3
ID: 1m1woscb_4
Snippet: Canonically, restriction factors are characterized by their ability to restrict viruses in non-natural hosts and have undergone positive selection due to viral antagonism. We find here that while nonhuman primate IFITM proteins are in general more potent to restrict HIV-1, they are still highly effective against some strains of SIVs derived from their own natural hosts. Moreover, phylogenetic analysis shows that primate IFITM proteins have been u.....
Document: Canonically, restriction factors are characterized by their ability to restrict viruses in non-natural hosts and have undergone positive selection due to viral antagonism. We find here that while nonhuman primate IFITM proteins are in general more potent to restrict HIV-1, they are still highly effective against some strains of SIVs derived from their own natural hosts. Moreover, phylogenetic analysis shows that primate IFITM proteins have been undergoing purifying selection, suggesting that the primary amino acid sequences of IFITMs are essential for their structure and functions, which is atypical for restriction factors.
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