Author: Muñoz-González, Sara; Ruggli, Nicolas; Rosell, Rosa; Pérez, Lester Josué; Frías-Leuporeau, Maria Teresa; Fraile, Lorenzo; Montoya, Maria; Cordoba, Lorena; Domingo, Mariano; Ehrensperger, Felix; Summerfield, Artur; Ganges, Llilianne
Title: Postnatal Persistent Infection with Classical Swine Fever Virus and Its Immunological Implications Document date: 2015_5_4
ID: 13cii3on_37
Snippet: Because IL-10 production could be stimulated with virus only in the PBMCs from the persistently infected piglets (Fig 7) and because there were no IFN-γ producing cells in the stimulated PBMCs from these animals (Fig 4C) , the number of IFN-γ-producing cells upon CSFV stimulation was determined with or without the presence of the anti-IL-10 neutralising antibody (Ab). Additionally, the addition of anti-IL-10 Ab alone to PBMC cultures in the abs.....
Document: Because IL-10 production could be stimulated with virus only in the PBMCs from the persistently infected piglets (Fig 7) and because there were no IFN-γ producing cells in the stimulated PBMCs from these animals (Fig 4C) , the number of IFN-γ-producing cells upon CSFV stimulation was determined with or without the presence of the anti-IL-10 neutralising antibody (Ab). Additionally, the addition of anti-IL-10 Ab alone to PBMC cultures in the absence of antigen had no effect (data not shown). However, despite the anti-IL-10 Ab in the PBMC culture from persistently infected piglets, the response of the IFN-γ-producing cells was not restored (Fig 8) . Nevertheless, IFN-γ production by PBMCs from non-infected piglets was significantly increased in the presence of anti-IL-10 neutralising Ab.
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