Selected article for: "genomic sequence and host origin"
Author: Ping Liu; Jing-Zhe Jiang; Xiu-Feng Wan; Yan Hua; Xiaohu Wang; Fanghui Hou; Jing Chen; Jiejian Zou; Jinping Chen
Title: Are pangolins the intermediate host of the 2019 novel coronavirus (2019-nCoV) ?
  • Document date: 2020_2_20
    • ID: 2inlyd0t_23
    Snippet: Compared to the genomic sequence of pangolin-CoV-2020 we assembled in this study, phylogenetic trees suggested that a bat origin coronavirus (i.e., Bat-CoV-RaTG13) was more genetically close to the 2019-nCoV at both individual gene and genomic sequence level. Interestingly, the cleavage site between S1 and S2 at the 2019-nCoV had multiple insertions (i.e. PRRA), compared to that of Bat-CoV-RaTG13 and pangolin-CoV-2020, which were similar. Thus, a.....
    Document: Compared to the genomic sequence of pangolin-CoV-2020 we assembled in this study, phylogenetic trees suggested that a bat origin coronavirus (i.e., Bat-CoV-RaTG13) was more genetically close to the 2019-nCoV at both individual gene and genomic sequence level. Interestingly, the cleavage site between S1 and S2 at the 2019-nCoV had multiple insertions (i.e. PRRA), compared to that of Bat-CoV-RaTG13 and pangolin-CoV-2020, which were similar. Thus, although it is clear that 2019-nCoV is of bat origin, it is likely another intermediate host could be involved in emergence of the 2019-nCoV.

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