Author: Marriott, Andrew S.; Vasieva, Olga; Fang, Yongxiang; Copeland, Nikki A.; McLennan, Alexander G.; Jones, Nigel J.
Title: NUDT2 Disruption Elevates Diadenosine Tetraphosphate (Ap(4)A) and Down-Regulates Immune Response and Cancer Promotion Genes Document date: 2016_5_4
ID: 0ozzbp85_57
Snippet: Other genes repressed by HINT1 through its interaction with MITF, USF2 or the WNT/βcatenin complex include cyclin D1 (CCND1), BCL2, BIRC5, MET, MYC, FRA1, TGFB, HIF1A, PAI-1 (SERPINE1) and AXIN2 [139] [140] [141] . Of these, BCL2, MYC and AXIN2 were slightly upregulated 1.3-, 1.3-and 2.4-fold while CCND1 was down-regulated 6.2-fold. Loss of HINT1 has also been reported to reduce the expression of p21 WAF1/CIP1 (CDKN1A), GADD45A, GADD153 and TP53.....
Document: Other genes repressed by HINT1 through its interaction with MITF, USF2 or the WNT/βcatenin complex include cyclin D1 (CCND1), BCL2, BIRC5, MET, MYC, FRA1, TGFB, HIF1A, PAI-1 (SERPINE1) and AXIN2 [139] [140] [141] . Of these, BCL2, MYC and AXIN2 were slightly upregulated 1.3-, 1.3-and 2.4-fold while CCND1 was down-regulated 6.2-fold. Loss of HINT1 has also been reported to reduce the expression of p21 WAF1/CIP1 (CDKN1A), GADD45A, GADD153 and TP53INP1 [142] but only the predicted slight reduction in CDKN1A expression (1.4-fold) was observed in NuKO cells. Thus, there is no clear evidence to support the relief of HINT1 repression of transcription factors as a cause of Ap 4 A-mediated differential gene expression in KBM-7 cells.
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