Selected article for: "apoptotic cell and cell lysis"

Author: Dai, Xiaofeng; Hakizimana, Olivier; Zhang, Xuanhao; Kaushik, Aman Chandra; Zhang, Jianying
Title: Orchestrated efforts on host network hijacking: Processes governing virus replication
  • Document date: 2020_2_12
  • ID: 1dc46btc_19
    Snippet: Non-apoptotic programmed cell death Viruses can evoke or suppress several types of nonapoptotic programmed cell death such as pyroptosis and necroptosis. Pyroptosis is characterized by cell lysis and an inflammatory response and may occur as an antiviral immune response to virus infection. For instance, enterovirus 71 (EV71) and coxsackievirus B3 (CVB3) infections activate host pyroptosis, which is accompanied by IL-1β and IL-18 secretion [64] ......
    Document: Non-apoptotic programmed cell death Viruses can evoke or suppress several types of nonapoptotic programmed cell death such as pyroptosis and necroptosis. Pyroptosis is characterized by cell lysis and an inflammatory response and may occur as an antiviral immune response to virus infection. For instance, enterovirus 71 (EV71) and coxsackievirus B3 (CVB3) infections activate host pyroptosis, which is accompanied by IL-1β and IL-18 secretion [64] . Necroptosis is marked by rupture of the plasma membrane and release of proinflammatory damage-associated molecular patterns (DAMPs), and plays pro-inflammatory roles against virus infection [65] . Viruses can suppress host necroptosis (e.g. disrupting RHIM-RHIM interactions between ZBP1 and RIPK3 or modulating the ubiquitination status of RIPK1 and RIPK3) by secreting necroptosis inhibitors such as ICP6 in HSV-1 [66] , ICP10 in HSV-2 [67] , and LMP1 in EBV [68] .

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