Orchestrated efforts on host network hijacking: Processes governing virus replication

Dai, Xiaofeng; Hakizimana, Olivier; Zhang, Xuanhao; Kaushik, Aman Chandra; Zhang, Jianying

During cell cycle state transitions, while most arrested cells are stuck at entry of the next state, some are arrested when exiting the current state ( Figure 4 ). Example strategies that attract cells in the mitotic state include the inhibition on anaphase-promoting complex (APC) by the apoptin protein of chicken anemia virus (CAV) [105] , interference with kinetochores by HSV-1 ICP0 protein, and sustained CDK1-cyclin B1 activity by the non-degradable cyclin B analog EC27 protein of baculovirus [106] . Human CMV arrests cells in the S stage by preventing them from genome replication through the IE2 viral protein [107] . HBV triggers hepatocytes exist G0 but stall in G1 through the HBx viral protein that takes advantage of mitochondrialdependent calcium signaling [108] .