Author: Kuban-Jankowska, Alicja; Sahu, Kamlesh K; Niedzialkowski, Pawel; Gorska, Magdalena; Tuszynski, Jack A; Ossowski, Tadeusz; Wozniak, Michal
Title: Redox process is crucial for inhibitory properties of aurintricarboxylic acid against activity of YopH: virulence factor of Yersinia pestis Document date: 2015_7_22
ID: 1irvzt8v_13
Snippet: We found that ATA inactivates YopH and CD45 phosphatases at nanomolar concentrations. Interestingly, considering IC 50 values, ATA was more effective against YopH from Y. pestis and YopH from Y. enterocolitica than against CD45 phosphatase ( Figure 1B ). Comparing the inhibitory effect of ATA with peroctanoic acid, ATA inactivated Y. pestis YopH with greater potency than peroctanoic acid, but peroctanoic acid was found to be a stronger inhibitor .....
Document: We found that ATA inactivates YopH and CD45 phosphatases at nanomolar concentrations. Interestingly, considering IC 50 values, ATA was more effective against YopH from Y. pestis and YopH from Y. enterocolitica than against CD45 phosphatase ( Figure 1B ). Comparing the inhibitory effect of ATA with peroctanoic acid, ATA inactivated Y. pestis YopH with greater potency than peroctanoic acid, but peroctanoic acid was found to be a stronger inhibitor of CD45 ( Figure 1B ).
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