Author: Stepanov, Grigory A.; Filippova, Julia A.; Komissarov, Andrey B.; Kuligina, Elena V.; Richter, Vladimir A.; Semenov, Dmitry V.
Title: Regulatory Role of Small Nucleolar RNAs in Human Diseases Document date: 2015_4_28
ID: 0ws5q37g_15
Snippet: Studies in mouse models have uncovered that adenoassociated virus integrates with high-frequency on chromosome 12 near Meg3 gene locus [42] . This region is rich in orphan snoRNA and microRNA genes. The integration of the viral genome causes aberrations in host-gene expression leading to hepatocellular carcinoma. The syntenic region in humans is proposed to encode tumor suppressor genes. The expression of the noncoding Meg3 transcript is severely.....
Document: Studies in mouse models have uncovered that adenoassociated virus integrates with high-frequency on chromosome 12 near Meg3 gene locus [42] . This region is rich in orphan snoRNA and microRNA genes. The integration of the viral genome causes aberrations in host-gene expression leading to hepatocellular carcinoma. The syntenic region in humans is proposed to encode tumor suppressor genes. The expression of the noncoding Meg3 transcript is severely suppressed in various cancer cell lines and tumor types, while the deletion of the corresponding genome locus leads to aggressive tumors [43] . Meg3 RNA upregulates p53 levels by downregulating Mdm2 levels and promotes angiogenesis by increasing Vegfa and Vegfr1 levels [44, 45] .
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