Author: Stepanov, Grigory A.; Filippova, Julia A.; Komissarov, Andrey B.; Kuligina, Elena V.; Richter, Vladimir A.; Semenov, Dmitry V.
Title: Regulatory Role of Small Nucleolar RNAs in Human Diseases Document date: 2015_4_28
ID: 0ws5q37g_22
Snippet: A homozygous 2 bp (TT) deletion in U50 snoRNA gene, encoded within the intron of U50HG (SNHG5), was found in prostate cancer cell lines [57] . The same, but often heterozygous, 2-nt mutation in U50HG (SNHG5) gene is present in breast cancer cells [58] . The deletion leads to the reduced expression of U50 snoRNA. In both cases the return to the wild-type expression level of the snoRNA results in inhibited cancer cell growth. The mutation was detec.....
Document: A homozygous 2 bp (TT) deletion in U50 snoRNA gene, encoded within the intron of U50HG (SNHG5), was found in prostate cancer cell lines [57] . The same, but often heterozygous, 2-nt mutation in U50HG (SNHG5) gene is present in breast cancer cells [58] . The deletion leads to the reduced expression of U50 snoRNA. In both cases the return to the wild-type expression level of the snoRNA results in inhibited cancer cell growth. The mutation was detected with diagnostically significant frequencies in blood cells of males with prostate cancer and females with breast cancer [57, 58] . The data allowed identifying U50 box C/D RNA as a tumor suppressor.
Search related documents:
Co phrase search for related documents- blood cell and breast cancer cell: 1, 2
- blood cell and cancer cell: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- blood cell and cancer cell growth: 1, 2
- blood cell and cancer cell line: 1, 2
- blood cell and cell growth: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14
- blood cell and cell line: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- blood cell and prostate cancer: 1, 2, 3
- blood cell and reduced expression: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10
- blood cell and tumor suppressor: 1
- blood cell and wild type: 1, 2, 3, 4, 5, 6, 7, 8
- breast cancer and cancer cell growth: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10
- breast cancer and cancer cell line: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- breast cancer and cell growth: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- breast cancer and cell line: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- breast cancer and prostate cancer: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- breast cancer and reduced expression: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11
- breast cancer and tumor suppressor: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22
- breast cancer and wild type: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10
- breast cancer and wild type expression: 1
Co phrase search for related documents, hyperlinks ordered by date