Author: Stepanov, Grigory A.; Filippova, Julia A.; Komissarov, Andrey B.; Kuligina, Elena V.; Richter, Vladimir A.; Semenov, Dmitry V.
Title: Regulatory Role of Small Nucleolar RNAs in Human Diseases Document date: 2015_4_28
ID: 0ws5q37g_23
Snippet: Expression profile of snoRNA and scaRNA genes was analyzed with quantitative RT-PCR in leukemic cells of different origin-AML, T-ALL and pre-B ALL, Burkitt's lymphoma/leukemia, and a solid tumor (HeLa cell line) [59] . Box C/D and box H/ACA snoRNA expression profiles were found to vary within different types and subtypes of cancer, with different leukemia subtypes sharing the most similarity. That difference in snoRNA levels enables us to use sno.....
Document: Expression profile of snoRNA and scaRNA genes was analyzed with quantitative RT-PCR in leukemic cells of different origin-AML, T-ALL and pre-B ALL, Burkitt's lymphoma/leukemia, and a solid tumor (HeLa cell line) [59] . Box C/D and box H/ACA snoRNA expression profiles were found to vary within different types and subtypes of cancer, with different leukemia subtypes sharing the most similarity. That difference in snoRNA levels enables us to use snoRNA and scaRNA patterns for characterization and classification of cancer types [59] . Diagnostically useful differences in snoRNA expression profiles were also reported for different BioMed Research International 5 subtypes of T-cell lymphoma [60] . Elevated level of box C/D RNA HBII-239 and its microRNA derivative miRNA-768-3p in peripheral T-cell lymphoma was detected in cases with favorable outcomes.
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