Author: Moss, Ronald B
Title: Prospects for control of emerging infectious diseases with plasmid DNA vaccines Document date: 2009_9_7
ID: 1a5u7uux_4
Snippet: Shortly after these original observations, many groups including those led by Liu and colleagues at Merck Research Laboratories [4] , Weiner and colleagues at University of Pennsylvania [5] , Johnston and colleagues at University of Texas [6] , Robinson and colleagues at University of Massachusetts [7] , and Hoffman and colleagues at Naval Medical Research Center [8] , demonstrated that immunization with DNA could result in the production of fore.....
Document: Shortly after these original observations, many groups including those led by Liu and colleagues at Merck Research Laboratories [4] , Weiner and colleagues at University of Pennsylvania [5] , Johnston and colleagues at University of Texas [6] , Robinson and colleagues at University of Massachusetts [7] , and Hoffman and colleagues at Naval Medical Research Center [8] , demonstrated that immunization with DNA could result in the production of foreign proteins or antigens that stimulate the immune system resulting in protection from or amelioration of infectious diseases in animal models. Development in this area has greatly advanced over the years and human clinical trials of DNA vaccines have now been conducted against various infectious pathogens including the malaria parasite, dengue viruses, cytomegalovirus (CMV), Ebola virus, seasonal influenza viruses, avian or pandemic influenza viruses, West Nile virus (WMV), SARS coronavirus, hepatitis B virus, and HIV.
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