Author: Girsch, James H.; Walters, Katherine; Jackson, Wallen; Grose, Charles
Title: Progeny Varicella-Zoster Virus Capsids Exit the Nucleus but Never Undergo Secondary Envelopment during Autophagic Flux Inhibition by Bafilomycin A1 Document date: 2019_8_13
ID: 1qbklvqy_16
Snippet: Through the use of the vacuolar proton ATPase inhibitor BAF, this study confirmed the centrality of the Golgi apparatus/TGN as a platform in the VZV infectious cycle. There were two important conclusions, both of which required visualization of the infected monolayers by electron microscopy. The most important conclusion was that the reduced VZV titers secondary to BAF treatment were caused by an apparent failure of secondary envelopment within a.....
Document: Through the use of the vacuolar proton ATPase inhibitor BAF, this study confirmed the centrality of the Golgi apparatus/TGN as a platform in the VZV infectious cycle. There were two important conclusions, both of which required visualization of the infected monolayers by electron microscopy. The most important conclusion was that the reduced VZV titers secondary to BAF treatment were caused by an apparent failure of secondary envelopment within a VAC. Capsids were transported through the inner nuclear membrane, some of which were detected within the perinuclear space more
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