Author: Pan, Yen-Yu; Wang, Shiu-Mei; Huang, Kuo-Jung; Chiang, Chien-Cheng; Wang, Chin-Tien
Title: Placement of Leucine Zipper Motifs at the Carboxyl Terminus of HIV-1 Protease Significantly Reduces Virion Production Document date: 2012_3_1
ID: 09locmnw_21
Snippet: Several researchers have suggested that the PR-mediated initial cleavage occurs via an intramolecular mechanism [37, 38, 39, 40, 41] . Although we did not search for the presence of a PR dimer, PR was theoretically capable of being released from the chimera as a fully processed dimer, since the cleavage site at the PR/LZ junction remained intact. Compared to the wt LZ fusion, the placement of a mutant LZ (Kz) at either the N-or Cterminus of the w.....
Document: Several researchers have suggested that the PR-mediated initial cleavage occurs via an intramolecular mechanism [37, 38, 39, 40, 41] . Although we did not search for the presence of a PR dimer, PR was theoretically capable of being released from the chimera as a fully processed dimer, since the cleavage site at the PR/LZ junction remained intact. Compared to the wt LZ fusion, the placement of a mutant LZ (Kz) at either the N-or Cterminus of the wt LZ (Wz) resulted in reduced Gag cleavage efficiency (Fig. 2) . This may be attributable to the inability of WKz or KWz to promote Gag-PR multimerization (Fig. 4E) .
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