Author: Delvecchio, Rodrigo; Higa, Luiza M.; Pezzuto, Paula; Valadão, Ana Luiza; Garcez, Patrícia P.; Monteiro, Fábio L.; Loiola, Erick C.; Dias, André A.; Silva, Fábio J. M.; Aliota, Matthew T.; Caine, Elizabeth A.; Osorio, Jorge E.; Bellio, Maria; O’Connor, David H.; Rehen, Stevens; de Aguiar, Renato Santana; Savarino, Andrea; Campanati, Loraine; Tanuri, Amilcar
Title: Chloroquine, an Endocytosis Blocking Agent, Inhibits Zika Virus Infection in Different Cell Models Document date: 2016_11_29
ID: 01s21vh0_34
Snippet: Considering that ZIKV infects hBMECs [32] , we investigated whether chloroquine could inhibit viral infection of these cells. Chloroquine reduced 45% and 50% of the number of ZIKV MR766-infected hBMECs at 25 and 50 µM, respectively ( Figure 4A,D) . These concentrations are non-cytotoxic ( Figure 4B ), and protected approximately 80% of hBMECs from ZIKV infection as demonstrated by the increase in cell viability ( Figure 4C )......
Document: Considering that ZIKV infects hBMECs [32] , we investigated whether chloroquine could inhibit viral infection of these cells. Chloroquine reduced 45% and 50% of the number of ZIKV MR766-infected hBMECs at 25 and 50 µM, respectively ( Figure 4A,D) . These concentrations are non-cytotoxic ( Figure 4B ), and protected approximately 80% of hBMECs from ZIKV infection as demonstrated by the increase in cell viability ( Figure 4C ).
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