Author: van Zuylen, Wendy J.; Doyon, Priscilla; Clément, Jean-François; Khan, Kashif Aziz; D'Ambrosio, Lisa M.; Dô, Florence; St-Amant-Verret, Myriam; Wissanji, Tasheen; Emery, Gregory; Gingras, Anne-Claude; Meloche, Sylvain; Servant, Marc J.
Title: Proteomic Profiling of the TRAF3 Interactome Network Reveals a New Role for the ER-to-Golgi Transport Compartments in Innate Immunity Document date: 2012_7_5
ID: 1m5dbwjv_19
Snippet: Additionally, we addressed the association of TRAF3 with p115-and Sec16A-containing complexes upon PAMP exposure. In unstimulated cells, a weak but constitutive association of endogenous TRAF3 with endogenous Sec16A and p115 was detected ( Figure 5 A and B) . However, upon viral infection or transfection with poly I:C or poly dA:dT, immunocomplexes containing endogenous TRAF3 were enriched with p115 and Sec16A. Importantly, the induced associatio.....
Document: Additionally, we addressed the association of TRAF3 with p115-and Sec16A-containing complexes upon PAMP exposure. In unstimulated cells, a weak but constitutive association of endogenous TRAF3 with endogenous Sec16A and p115 was detected ( Figure 5 A and B) . However, upon viral infection or transfection with poly I:C or poly dA:dT, immunocomplexes containing endogenous TRAF3 were enriched with p115 and Sec16A. Importantly, the induced association of TBK1 with TRAF3 closely mirrored the presence of p115 and Sec16A. ( Figure 5B ). From these results we hypothesized that the localization of TRAF3 to the ER-to-Golgi compartment and the Golgi fragmentation of the latter into punctate structures might be required for the proper positioning of TRAF3 with MAVS.
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