Selected article for: "etiological agent and MERS cov"
Author: Cao, Liyan; Ge, Xuying; Gao, Yu; Herrler, Georg; Ren, Yudong; Ren, Xiaofeng; Li, Guangxing
Title: Porcine epidemic diarrhea virus inhibits dsRNA-induced interferon-ß production in porcine intestinal epithelial cells by blockade of the RIG-I-mediated pathway
  • Document date: 2015_8_18
    • ID: 0qt7eth0_1
    Snippet: Porcine epidemic diarrhea virus (PEDV) is an enveloped, single-stranded, RNA virus of Coronaviridae family, which is the main etiological agent of severe diarrhea in pigs of all ages and fatality in neonates [1] . Outbreaks of porcine epidemic diarrhea (PED) have received extensive attention for the considerable economic losses to the swine industry worldwide. Great advances have been made in elucidation of the molecular epidemiology, diagnosis, .....
    Document: Porcine epidemic diarrhea virus (PEDV) is an enveloped, single-stranded, RNA virus of Coronaviridae family, which is the main etiological agent of severe diarrhea in pigs of all ages and fatality in neonates [1] . Outbreaks of porcine epidemic diarrhea (PED) have received extensive attention for the considerable economic losses to the swine industry worldwide. Great advances have been made in elucidation of the molecular epidemiology, diagnosis, prevention, and treatment of PED [2] . Recently, coronavirus interaction with host innate immune system has been a hot research field. Previous studies indicated that transmissible gastroenteritis virus (TGEV) infection enhanced type I interferon expression and its protein 7 modulated type I IFN expression [3, 4] . For mouse hepatitis virus (MHV), IFN production among different cell populations varied due to their diverse susceptibility to this virus [5] [6] [7] [8] [9] . Furthermore, both severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV) do not induce type I IFN (IFN-α/ β) activation [10] [11] [12] . So far, limited reports showed that PEDV could inhibit type I interferon production [13, 14] .

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